Postdoctoral Associate

About this position

Description & Requirements

• The Broad Institute of MIT & Harvard is seeking a highly motivated
• Postdoctoral Associate to join the Xavier Lab and Klarman Cell
• Observatory and lead data analysis and algorithm development designed
• to determine the underlying factors contributing to health and
• disease, with a strong focus on discovering disease mechanisms at the
• level of their molecular and cellular pathways.

• We are an interdisciplinary group with expertise in computational
• biology, functional genomics, microbiology, and immunology. The
• candidate for this position will be working closely with computational
• and experimental biologists, including Principal Investigators,
• graduate students, and staff scientists in the group. They will
• contribute by directing, planning, and executing the analyses of large
• multi-omic datasets with the goal of identifying biological features
• (e.g., variants, genes, microbes) that are relevant to human health.
• Prospective applicants should have made significant contributions to
• their area of study, as evidenced by a strong publication record. We
• are seeking creative and highly motivated individuals who want to work
• in a dynamic, multi- disciplinary research environment.

• The ideal candidate will be the computational analysis lead for
• projects discovering the mechanisms behind inflammatory and autoimmune
• diseases. They should have excellent technical expertise while being
• driven to make a biological impact. In particular, we are seeking a
• postdoc to take primary leadership for analyzing spatial and
• single-cell multiomics datasets collected from human tissue samples as
• well as mouse models.

Responsibilities

• Oversee data generation and data analysis across various internal
• and external collaborations. Includes working datasets such as
• single-cell RNA-Seq, single-cell ATAC-Seq, spatial
• transcriptomics, proteomics, metabolomics, and/or microbiome data.

Demonstrate flexibility to execute tasks requiring various skill

levels and learn new skills as needed.

• Perform analyses using current processes and identify, propose,
• and implement improvements to ensure output of high-quality
• datasets.

• Work with other team members and leadership to plan project
• requirements and timelines, shift priorities as needed, and
• efficiently execute project tasks.

• Identify and help solve methodological problems, including
• adjustments to experimental and computational protocols to ensure
• generation of high-quality datasets suited to answer core
• biological questions.

• Use single cell and spatial transcriptomic approaches to
• understand tissue organization and how they are altered in disease
• environments such as chronic inflammation.

Use a systems medicine approach to understand inflammatory and

other diseases.

Develop novel methods to facilitate exploration of unstructured

datasets.

Write well-crafted, maintainable, scalable, and performant code.

Lead and carry out projects with minimal supervision.

Participate in writing papers and grant proposals.

Present project progress during group meetings.

Qualifications

• Ph.D. in Computational Biology, Computer Science, Physics, Math,
• Statistics, or related quantitative fields and strong knowledge of
• a variety of biological areas of research with 0+ years of
• experience within the field.

Scientific and numerical programming in Python or R and knowledge

of class ML methods and deep learning methods.

• Well versed in a variety of bioinformatic analyses, including Next
• Generation Sequencing pipelines (single-cell RNA-Seq, single-cell
• ATAC-Seq, spatial transcriptomics analyses etc...).

Excellent critical thinking, research, and analytical skills.

• Excellent communication and interpersonal skills and the ability
• to work with biologists, computational biologists, data
• scientists, and software engineers.

Must be able to work independently as well as part of a team in a

fast-paced, highly collaborative environment.

• Demonstrated ability to carry out a variety of tasks in parallel,
• recognize and solve problems effectively, and shift priorities
• rapidly.

Selected Publications

Intra- and Inter-cellular Rewiring of the Human Colon during

Ulcerative Colitis

https://pubmed.ncbi.nlm.nih.gov/31348891/

The landscape of immune dysregulation in Crohn's disease revealed

through single-cell transcriptomic profiling in the ileum and colon

https://pubmed.ncbi.nlm.nih.gov/36720220/

Bidirectional CRISPR screens decode a GLIS3-dependent fibrotic cell

circuit

https://pubmed.ncbi.nlm.nih.gov/41501466/

Population-scale multiome immune cell atlas reveals complex disease

drivers

https://www.medrxiv.org/content/10.1101/2025.11.25.25340489v1

A structure-informed deep learning framework for modeling

TCR-peptide-HLA interactions

https://www.biorxiv.org/content/10.64898/2026.03.31.715361v2.full

Bridging AI and biology: Foundation models meet human physiology and

disease

https://pubmed.ncbi.nlm.nih.gov/41519120/

• The expected base pay range for this position as listed above is based
• on a 40 hour per week schedule. Broad provides pay ranges representing
• its reasonable and good faith estimate of what the organization
• reasonably expects to pay for a position at the time of posting.
• Actual compensation will vary based on factors including but not
• limited to, relevant skills, experience, education, qualifications,
• and other factors permissible by law.

• At Broad, your base pay is just one part of a comprehensive total
• rewards package. From day one, this role offers a competitive benefits
• package including medical, dental, vision, life, and disability
• insurance; a 401(k) retirement plan; flexible spending and health
• savings accounts; at least 13 paid holidays; winter closure; paid time
• off; parental and family care leave; and an employee assistance
• program, among other Broad benefits.
• The Broad Institute is an equal opportunity employer. All qualified
• applicants will receive consideration for employment without regard to
• race, national origin, religion, age, color, sex, disability,
• protected veteran status, or any other characteristic protected by
• local, state, or federal laws, rules, or regulations.
• Should you need a reasonable accommodation to complete the application
• or interview process, please contact recruiting@broadinstitute.org for
• assistance.