About this position
Liver Cancer and Ultrasound Imaging Postdoc Fellowship
- Location:
- University of Pennsylvania – Perelman School of Medicine
- Open Date:
- Aug 10, 2026
- Description:
- Description
Mentor: Chandra Sehgal, PhD
Hiring Department: Radiology
Funding Source: NIH
Number of positions: 1
U.S. Citizens and foreign nationals may apply
Project overview
The ultrasound research lab is developing hydralazine-augmented contrast ultrasound (HyCUS), a novel functional imaging technique that exploits differences in tumor versus liver vasculature to improve early detection of hepatocellular carcinoma (HCC), the fastest-growing cause of cancer death in the U.S. Our preliminary data show HyCUS more than triples lesion visibility compared to standard B-mode and contrast-enhanced ultrasound, and detects small HCC lesions missed entirely by current clinical methods. We are seeking a motivated postdoctoral fellow to help translate this promising discovery from bench to bedside.
Research Activity
The candidate will lead validation studies in an autochthonous rat model of HCC with liver fibrosis, working across three interconnected aims: establishing the biological basis of HyCUS, defining an optimal hydralazine dosing regimen, and benchmarking HyCUS against existing sonographic surveillance methods. The investigator will work at the intersection of cancer biology, vascular pharmacology, and noninvasive imaging. The position provides an opportunity to shape a translational imaging technology from preclinical proof of concept toward eventual clinical application.
Qualifications:
- PhD, MD/PhD, or equivalent doctoral degree in Biomedical Engineering, Bioengineering, Chemical Engineering, Pharmacology, Imaging Sciences, or a related field.
- Background and interest in tumor biology, vascular physiology, or pharmacology
- Hands-on experience with animal models and histology is required
- Interest in contrast-enhanced ultrasound imaging
- Strong analytical and writing skills; interest in building an independent research trajectory
We will provide training in any missing technical skills for motivated candidates.
Application Instructions:
To apply, please submit the following through Interfolio:
Brief statement of your research experience and interestsCurriculum VitaeName and contact information of three references.
Equal Employment Opportunity Statement:
The University of Pennsylvania is an equal opportunity employer. Candidates are considered for employment without regard to race, color, sex, sexual orientation, religion, creed, national origin (including shared ancestry or ethnic characteristics), citizenship status, age, disability, veteran status or any class protected under applicable federal, state, or local law.
How to apply
- Read the full advert on the source site — it carries the authoritative terms.
- Prepare your SOP, CV, transcripts and referees before the deadline.
- Apply through the university's own portal. Never pay a fee to a third party.