Research fellow, regulation of aging

About this position

[Background of the recruitment and description of the project]

• Background of the recruitment and description of the project

Rejuvenation and aging research are gaining significant attention in the fields of biotechnology and biomedical science, with increasing investment and development activity. A key focus is on understanding and reversing aging at the molecular and cellular levels, particularly through the lens of the epigenome. This includes not only objective prediction of biological aging, but also the improvement of age-related phenotypes such as cognitive decline, muscle weakness, bone density loss, and kidney dysfunction.

Our research is particularly interested in how environmental and lifestyle factors—such as diet and daily habits—affect not just disease risk but also physical function. We aim to uncover the underlying molecular mechanisms and clarify how they influence both the "rate" and "onset" of aging.

At our laboratory, we are currently recruiting Special Research Scientists who are motivated to contribute to aging and age-related disease research. Our studies utilize various models including ICE mice and non-model organisms such as fish and birds, and cover areas such as dementia, sarcopenia, and age-related macular degeneration.

We welcome researchers from diverse backgrounds—from wet-lab biology to dry-lab fields such as AI and data science. Additionally, we encourage individuals who are interested in exploring aging research from outside traditional life sciences, including those aiming to translate research findings into real-world applications or entrepreneurship.

[Work content and job description]

As part of the Regulation of Ageing project, we are looking for researchers who will be responsible for the following tasks:

• Investigating the promotion and regulation of ageing through the Epigenome, which involves examining histone and DNA modifications to establish a novel ageing model using the ICE mouse.

• Exploring various perspectives on the rate and timing of ageing, including stem cells, DNA damage, epigenome, mitochondria, and lipid metabolism in ageing models. The use of AI and Deep Learning for data analysis and the establishment of in vitro ageing experimental systems and factor isolation using CRISPR Screening are also planned.

• Analyzing brain neural circuits and cellular functions (including nsRNA-seq) in brain regulation from the retina via the non-visual receptor OPN5, which can be applied to conditions such as depression, dementia, and Parkinson's disease.

• Investigating the effects of external signals on the body and ageing regulation, which may provide valuable insight into effective ageing control methods for conditions such as sarcopenia and dementia.

• Developing drugs to target factors in both ICE mice and OPN5 for effective ageing control, as well as conducting research to establish start-up companies focused on social implementation of ageing control methods.

• Assigned department

Existing departments

[Work location]

• Address

278-8510 Chiba 3rd Floor, Building 10, 2641 Yamazaki, Noda-shi,

[Number of hired]

Number of hired:2 person(s)