Postdoctoral Researcher (M/F) in Cell and Molecular Biology – 24 months Role of the RNA Damage Response in Cellular Plasticity and Chemotherapy Resistance in Lymphomas

About this position

Cellular plasticity is a major mechanism by which tumor cells adapt to microenvironmental constraints, particularly nutrient deprivation. In lymphomas, resistance to chemotherapy, including asparaginase-based treatments, is partly driven by the activation of molecular pathways that enable tumor cells to adapt to stress and maintain their survival. This project aims to characterize the signaling pathways and RNA Damage Response (RDR) mechanisms involved in cellular plasticity and therapeutic escape in lymphoma.

In particular, we will investigate how alterations in RNA integrity and function are sensed and integrated by tumor cells to remodel their cellular state, metabolism, and survival capacity in response to treatment. The overall objective is to identify the molecular mechanisms linking cellular stress, plasticity, and therapeutic resistance, thereby uncovering new cellular and metabolic vulnerabilities that could be exploited to develop targeted therapeutic strategies in oncology.

With a PhD in cellular and molecular biology, the successful candidate should have a strong scientific background, both theoretical and practical, in cellular stress signaling pathways, regulation of ribosome biogenesis, translation, and cell fate, as demonstrated by scientific publications.

The successful candidate is expected to demonstrate a high degree of autonomy, rigor, excellent organizational skills, and strong scientific communication and reporting abilities. They will also contribute to the collective activities of the research team and laboratory, as well as to the dissemination and valorization of research findings.

This position is based at the Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (LBTI – CNRS UMR 5305, Université Claude Bernard Lyon 1), located in the heart of the dynamic Lyon-Gerland Biodistrict. The successful candidate will join the research team led by Dr Cédric Chaveroux and contribute to the development of an INCa PLBIO-funded project, conducted in close collaboration with academic partners in Nice and Paris. Occasional travel as part of these collaborations will be required.